Abstract
Natural gamma-butyrolactone - (4R, 5R)-5-(4'-methyl-3'pentenyl)-4-hydroxy-5-methyl-dihydrofuran-2-one (2) was isolated as the product of microbial transformation of nerylacetone (1) by fungal strains. This product was obtained as the enantiomer (+) in high yields 24% and 61% with ee=94% and 82% by the biotransformation in the cultures of Acremonium roseum AM336 and Fusarium oxysporum AM13 respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / chemistry
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4-Butyrolactone / metabolism*
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Acetone / analogs & derivatives*
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Acetone / chemistry
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Acremonium / chemistry
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Acremonium / metabolism*
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Biotransformation
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Cell Line, Tumor
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Chromatography, Gas
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Drug Screening Assays, Antitumor
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Fusarium / chemistry
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Fusarium / metabolism*
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Humans
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Magnetic Resonance Spectroscopy
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Spectrophotometry, Infrared
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Tetrazolium Salts
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Thiazoles
Substances
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Tetrazolium Salts
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Thiazoles
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Acetone
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thiazolyl blue
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nerylacetone
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4-Butyrolactone