Stabilization of multiple level spine fractures in blunt trauma victims is an extensive and complicated surgical procedure. A multidisciplinary approach to the thoracolumbar anatomy and subsequent stabilization poses a variety of challenges to the neurosurgical operating room staff. Transfer to the operating table and positioning for the procedure are dictated by the following treatment protocol for vertebral fractures: immobilization and stabilization of fractures with skin or skeletal traction, administration of parenteral muscle relaxants and analgesics, assessment and documentation of neurologic status, maintenance of bone and joint alignment and provision of skin care. Standard preoperative preparation and intraoperative nursing diagnoses and interventions are discussed. The importance of communication and psychological support to family members is stressed.