Synthesis of Pyrrolo[1,2-a]quinoxalines via gold(I)-mediated cascade reactions

ACS Comb Sci. 2011 May 9;13(3):209-13. doi: 10.1021/co1000844. Epub 2011 Apr 13.

Abstract

In this study, we developed an efficient tandem process of hydroamination and hydroarylation using a gold catalyst to enable and study the reactions between pyrrole-substituted anilines and alkynes. The gold(I)-catalyzed reactions were achieved in toluene at 80 °C over a reaction time of 1−6 h. These reactions are applicable to a variety of aromatic amino compounds and both the terminal and internal alkynes. Substituted pyrrolo[1,2-a]quinoxalines were obtained in moderate to excellent yields. A presumed mechanism involving intermolecular C−N bond formation and intramolecular nucleophilic reaction via a cationic gold complex has been proposed on the basis of the deuterium labeling studies.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gold / chemistry*
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry
  • Quinoxalines / chemical synthesis*
  • Quinoxalines / chemistry
  • Temperature

Substances

  • Pyrroles
  • Quinoxalines
  • pyrrolo(1,2-a)quinoxaline
  • Gold