Two-dimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis

Fertil Steril. 2011 Jun 30;95(8):2764-8. doi: 10.1016/j.fertnstert.2011.03.061. Epub 2011 Apr 16.

Abstract

Endometriosis is determined by local and systemic proinflammatory dysregulation and therefore differential protein expression in peritoneal fluid (PF). Of highest interest is lesion formation and the establishment and persistence of endometriosis. In this study we analyzed well-characterized PF samples of patients with ovarian or peritoneal endometriosis and compared them to control samples. We found 11 proteins differentially regulated, of which some might play a key role in the pathogenesis of endometriosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Ascitic Fluid / chemistry*
  • Biomarkers / analysis
  • Case-Control Studies
  • Electrophoresis, Gel, Two-Dimensional*
  • Endometriosis / diagnosis
  • Endometriosis / metabolism*
  • Female
  • Germany
  • Humans
  • Middle Aged
  • Ovarian Diseases / diagnosis
  • Ovarian Diseases / metabolism*
  • Peritoneal Diseases / diagnosis
  • Peritoneal Diseases / metabolism*
  • Proteins / analysis*
  • Proteomics / methods*
  • Tandem Mass Spectrometry
  • Young Adult

Substances

  • Biomarkers
  • Proteins