Abstract
Sister chromatid cohesion and separation are two fundamental chromosome dynamics that are essential to equal chromosome segregation during cell proliferation. In this review, I will discuss the major steps that regulate these dynamics during mitosis, with an emphasis on vertebrate cells. The implications of these machineries outside of sister chromatid cohesion and separation are also discussed.
Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetyltransferases / genetics
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Acetyltransferases / metabolism
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Animals
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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Centromere / metabolism*
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Chondroitin Sulfate Proteoglycans / genetics
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Chondroitin Sulfate Proteoglycans / metabolism
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Chromatids / metabolism*
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism*
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Chromosome Segregation / physiology*
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Cohesins
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Endopeptidases / genetics
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Endopeptidases / metabolism
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Humans
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Mice
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Mitosis*
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Separase
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Signal Transduction
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Vertebrates
Substances
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Cell Cycle Proteins
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Chondroitin Sulfate Proteoglycans
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Chromosomal Proteins, Non-Histone
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SMC3 protein, human
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structural maintenance of chromosome protein 1
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Acetyltransferases
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ESCO1 protein, human
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ESCO2 protein, human
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Endopeptidases
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Separase