A case of refractory pyoderma gangrenosum treated with a combination of Apligraf and systemic immunosuppressive agents

Adv Skin Wound Care. 2011 May;24(5):217-20. doi: 10.1097/01.ASW.0000397898.56121.3f.

Abstract

Pyoderma gangrenosum (PG) is a rare inflammatory ulcerative skin disease. A case of refractory PG treated with a combination of immunosuppression and Apligraf (Organogenesis, Canton, Massachusetts) is presented. Under infliximab, systemic corticosteroids, and Apligraf, the wound showed a slow but complete healing. The authors demonstrated the potential benefits of Apligraf in the healing of PG.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Aged
  • Antibodies, Monoclonal / therapeutic use*
  • Collagen / therapeutic use*
  • Dermatologic Agents / therapeutic use*
  • Drug Therapy, Combination
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Infliximab
  • Latent Tuberculosis / drug therapy
  • Male
  • Pyoderma Gangrenosum / drug therapy*
  • Treatment Failure
  • Wound Healing
  • Wounds and Injuries / drug therapy

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal
  • Apligraf
  • Dermatologic Agents
  • Immunosuppressive Agents
  • Collagen
  • Infliximab