Abstract
Two novel biphenyl dimers, caesappanin A (1) and B (2), were isolated from the ethanol extract of the heartwood of Caesalpinia sappan. Their structures were elucidated on the basis of spectroscopic data including IR, HRESIMS, 1D and 2D NMR. Preliminary bioassays showed that compound 1 possessed potent cytotoxic effects against 4 cell lines including HCT-8, BGC-823, A549 and A2780 with IC(50) between 1.67μM and 4.88μM.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Biphenyl Compounds / isolation & purification*
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Biphenyl Compounds / pharmacology
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Biphenyl Compounds / therapeutic use
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Caesalpinia / chemistry*
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Cell Line, Tumor
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Humans
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Molecular Structure
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Phytotherapy
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Wood
Substances
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds
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Plant Extracts
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caesappanin A
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caesappanin B