Abstract
Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Aquaculture
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Cell Cycle Checkpoints / drug effects
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Cell Survival / drug effects*
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Flow Cytometry
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HL-60 Cells
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Humans
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Lactones / chemistry*
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Lactones / isolation & purification
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Microtubules / drug effects
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New Zealand
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Porifera / chemistry*
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Structure-Activity Relationship
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Thermodynamics
Substances
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Antineoplastic Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Lactones
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peloruside A