Abstract
In tumors characterized by a high osteotropism, such as multiple myeloma, the measurement of bone metabolism markers is helpful in monitoring both severity and prognosis of the skeletal disease. Here, we review the pathophysiology of these markers including tartrate resistant acid phosphatase (TRAcP), which appears highly specific and closely related to the extent of myeloma bone lesions.
MeSH terms
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Acid Phosphatase / blood
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Acid Phosphatase / metabolism*
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Biomarkers, Tumor / blood
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Biomarkers, Tumor / metabolism*
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Bone Neoplasms / blood
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Bone Neoplasms / enzymology*
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Bone Neoplasms / physiopathology
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Humans
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Isoenzymes / blood
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Isoenzymes / metabolism*
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Multiple Myeloma / blood
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Multiple Myeloma / enzymology*
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Multiple Myeloma / physiopathology
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Tartrate-Resistant Acid Phosphatase
Substances
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Biomarkers, Tumor
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Isoenzymes
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Acid Phosphatase
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Tartrate-Resistant Acid Phosphatase