Abstract
Cicletanine, when given p.o. either acutely or subchronically, was found to produce a clear-cut antihypertensive effect in the deoxycorticosterone salt experimental rat model. This compound was able to reverse high blood pressure, even at doses deprived of diuretic effect. Subchronic treatment (30 mg/kg, p.o.; 14 days) with cicletanine reduced the enhanced contractile response to noradrenaline in deoxycorticosterone salt rat aortic strips and reversed the cardiac hypertrophy in these animals. The antihypertensive effect after long-term treatment with cicletanine in deoxycorticosterone salt rats appears to be related to an antagonism of the elevated sympathetic drive to the vascular smooth muscle.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenalectomy
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Animals
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Antihypertensive Agents*
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Aorta, Thoracic / drug effects
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Blood Pressure / drug effects
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Blood Vessels / physiopathology*
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Cardiomegaly / drug therapy*
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Cardiomegaly / etiology
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Desoxycorticosterone
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Diuresis / drug effects
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Diuretics / pharmacology*
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Heart Rate / drug effects
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Hypertension / chemically induced
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Hypertension / complications
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Hypertension / physiopathology*
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Nephrectomy
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Norepinephrine / antagonists & inhibitors*
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Norepinephrine / pharmacology
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Pyridines*
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Rats
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Rats, Inbred Strains
Substances
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Antihypertensive Agents
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Diuretics
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Pyridines
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Desoxycorticosterone
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cicletanine
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Norepinephrine