Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents

Olga N Burchak; Emmanuelle Le Pihive; Laure Maigre; Xavier Guinchard; Pascale Bouhours; Claude Jolivalt; Dominique Schneider; Max Maurin; Carmela Giglione; Thierry Meinnel; Jean-Marc Paris; Jean-Noël Denis

doi:10.1016/j.bmc.2011.03.060

Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents

Bioorg Med Chem. 2011 May 15;19(10):3204-15. doi: 10.1016/j.bmc.2011.03.060. Epub 2011 Apr 2.

Authors

Olga N Burchak¹, Emmanuelle Le Pihive, Laure Maigre, Xavier Guinchard, Pascale Bouhours, Claude Jolivalt, Dominique Schneider, Max Maurin, Carmela Giglione, Thierry Meinnel, Jean-Marc Paris, Jean-Noël Denis

Affiliation

¹ Département de Chimie Moléculaire, UMR, CNRS, Université Joseph Fourier, Grenoble, France. [email protected]

PMID: 21515059
DOI: 10.1016/j.bmc.2011.03.060

Abstract

A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*
Bacterial Infections / drug therapy
Humans
Indoles / chemical synthesis
Indoles / chemistry*
Indoles / pharmacology*
Microbial Sensitivity Tests
Staphylococcal Infections / drug therapy
Staphylococcus aureus / drug effects
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Indoles