We have studied 3001 hepatitis B vaccination protocols, during the period 1982-89, in three hospitals of Zaragoza. 87.24% of the vaccinations have been conducted on health staff, meanwhile other epidemiological important groups (drug users) don't have been attended. The seroprevalence of HBsAg was 0.96% at the prevaccination study. The cleaning staff and the hemodialyzed patients had the greatest ones (5.69% and 3.33%). The administration of the vaccine failed due to rejection in 25.50% and to withdrawal in 8.09%. Only 8.65% don't have developed antibodies after vaccination.