Abstract
Pellagra is characterized by dermatitis, diarrhea, dementia and eventually death occurring as a result of niacin or its precursor tryptophan deficiency. Although pellagra is a well-known complication of isoniazid (INH) therapy, the clinical diagnosis may be missed or delayed that may cause life-threatening consequences. Due to the diversity of pellagra-related signs and symptoms, the diagnosis can be made with an appropriate index of suspicion. We report a 7-year-old boy presenting with INH-induced pellagra that resolved after the administration of the niacin therapy.
MeSH terms
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / adverse effects*
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Antitubercular Agents / therapeutic use
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Child
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Drug Therapy, Combination
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Humans
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Isoniazid / administration & dosage
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Isoniazid / adverse effects*
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Isoniazid / therapeutic use
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Male
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Niacinamide / administration & dosage
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Niacinamide / therapeutic use
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Pellagra / chemically induced*
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Pellagra / complications
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Pellagra / diagnosis
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Pellagra / drug therapy
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Treatment Outcome
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / drug therapy
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Vitamin B Complex / administration & dosage
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Vitamin B Complex / therapeutic use
Substances
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Antitubercular Agents
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Vitamin B Complex
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Niacinamide
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Isoniazid