Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

K Liaras; A Geronikaki; J Glamočlija; A Cirić; M Soković

doi:10.1016/j.bmc.2011.04.007

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

Bioorg Med Chem. 2011 May 15;19(10):3135-40. doi: 10.1016/j.bmc.2011.04.007. Epub 2011 Apr 7.

Authors

K Liaras¹, A Geronikaki, J Glamočlija, A Cirić, M Soković

Affiliation

¹ Aristotle University, School of Pharmacy, Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki, Greece.

PMID: 21524583
DOI: 10.1016/j.bmc.2011.04.007

Abstract

As part of ongoing studies in developing new antimicrobials, we report the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties. Evaluation of antibacterial activity showed that almost all the compounds exhibited greater activity than reference drugs and thus could be promising novel drug candidates.

MeSH terms

Anti-Infective Agents / chemical synthesis
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology*
Bacteria / drug effects*
Bacterial Infections / drug therapy
Chalcones / chemical synthesis
Chalcones / chemistry*
Chalcones / pharmacology*
Fungi / drug effects*
Humans
Mycoses / drug therapy
Structure-Activity Relationship
Thiazoles / chemical synthesis
Thiazoles / chemistry*
Thiazoles / pharmacology*

Substances

Anti-Infective Agents
Chalcones
Thiazoles