Abstract
In this work, we demonstrate that PtrA (U. H. Ha et al., Mol. Microbiol. 54:307-320, 2004) is a periplasmic protein, specifically synthesized in the presence of copper, that is involved in the tolerance of Pseudomonas aeruginosa to copper. Our biochemical and genetic analyses challenge its role in transcriptional inhibition of the type III secretion system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Copper / metabolism
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Copper / toxicity*
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Drug Resistance, Bacterial*
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Gene Expression Regulation, Bacterial
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Periplasmic Proteins / genetics
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Periplasmic Proteins / metabolism*
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Transcription, Genetic
Substances
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Bacterial Proteins
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Periplasmic Proteins
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Copper