Abstract
Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC(50) values of 2.26 and 1.82 μg/ml, and therapeutic index values of 35.5 and 18.6, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Fruit / chemistry
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HIV-1 / drug effects*
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Schisandra / chemistry*
Substances
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Anti-HIV Agents
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Drugs, Chinese Herbal
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Lignans
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rubrilignan A
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rubrilignan B