Synthesis of Pt@Fe2O3 nanorods as MRI probes for in vivo application

Yonggang Li; Yinjie Lu; Haiyan Hong; Yinyin Chen; Xinxing Ma; Liang Guo; Zhongling Wang; Jianhua Chen; Mo Zhu; Jiankun Ni; Hongwei Gu; Jianmei Lu; Jackie Y Ying

doi:10.1039/c1cc10758e

Synthesis of Pt@Fe2O3 nanorods as MRI probes for in vivo application

Chem Commun (Camb). 2011 Jun 14;47(22):6320-2. doi: 10.1039/c1cc10758e. Epub 2011 May 3.

Authors

Yonggang Li¹, Yinjie Lu, Haiyan Hong, Yinyin Chen, Xinxing Ma, Liang Guo, Zhongling Wang, Jianhua Chen, Mo Zhu, Jiankun Ni, Hongwei Gu, Jianmei Lu, Jackie Y Ying

Affiliation

¹ Department of Radiology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China 215006.

PMID: 21541416
DOI: 10.1039/c1cc10758e

Abstract

Magnetic Fe(2)O(3) nanorods with low cell toxicity were successfully synthesized via a wet-chemical method. In vivo studies with a rabbit model show that the nanorods exhibit excellent T(2) signal enhancement. This work demonstrates that magnetic nanorods may provide a new type of MR enhancement agent for use in biomedical applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Contrast Media / chemistry*
Contrast Media / pharmacokinetics
Ferric Compounds / chemistry*
Liver / metabolism
Magnetic Resonance Imaging
Metal Nanoparticles / chemistry
Metal Nanoparticles / ultrastructure
Mice
Nanotubes / chemistry*
Platinum / chemistry*
Rabbits

Substances

Contrast Media
Ferric Compounds
ferric oxide
Platinum