The role of limited surgery with irradiation in primary treatment of ductal in situ breast cancer

Int J Radiat Oncol Biol Phys. 1990 Feb;18(2):283-7. doi: 10.1016/0360-3016(90)90090-7.

Abstract

The results of management of ductal carcinoma in situ with limited surgery and radiotherapy are presented at a median follow-up of 92 months. In 44 treated breasts the actuarial 10-year loco-regional control rate was 91%, four patients having recurred. Each loco-regional failure was due to invasive carcinoma and three of the affected patients have developed metastases. No patient developed metastases without previous clinically-evident invasive loco-regional disease. The 10-year disease-specific survival rate was 96%. Previous publications have shown that the 25% or greater risk of local failure after limited excision of ductal carcinoma in situ can be reduced by irradiation of the breast. Our results demonstrate that good loco-regional control is maintained in the longer term.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / radiotherapy
  • Breast Neoplasms / surgery
  • Breast Neoplasms / therapy*
  • Carcinoma in Situ / radiotherapy
  • Carcinoma in Situ / surgery
  • Carcinoma in Situ / therapy*
  • Carcinoma, Intraductal, Noninfiltrating / radiotherapy
  • Carcinoma, Intraductal, Noninfiltrating / surgery
  • Carcinoma, Intraductal, Noninfiltrating / therapy*
  • Cobalt Radioisotopes / therapeutic use*
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Mastectomy, Segmental*
  • Middle Aged
  • Prognosis
  • Radioisotope Teletherapy*

Substances

  • Cobalt Radioisotopes