Abstract
Two pairs of epimeric indole alkaloids (1- 4) with a chlorine atom were isolated from the aerial part of Catharanthus roseus. Their structures were established on the basis of the spectroscopic data including UV, IR, HRESIMS, NMR, and X-ray diffraction analyses. The cytotoxic activities of 1-4 against the HepG2 cell line were evaluated.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Catharanthus / chemistry*
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Cell Survival
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Hep G2 Cells
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Humans
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Indole Alkaloids / chemistry*
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology
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Isomerism
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Molecular Structure
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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X-Ray Diffraction
Substances
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Antineoplastic Agents
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Indole Alkaloids
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Plant Extracts