New antimycobacterial triterpenoids from Rhus taitensis

Planta Med. 2011 Sep;77(14):1651-4. doi: 10.1055/s-0030-1271027. Epub 2011 May 3.

Abstract

Two new triterpenoids were isolated from the leaves and twigs of Rhus taitensis. Their structures were elucidated by 1D and 2D NMR spectroscopic studies as 1,10,24,25,30-pentahydroxysqualene and dammar-20(22),24-diene-3 β,26,27-triol. Both compounds exhibited moderate antimycobacterial activities with an MIC of 45 µg/mL.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Cell Survival
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / growth & development
  • Plant Extracts / chemistry*
  • Plant Leaves / chemistry
  • Plants, Medicinal
  • Rhus / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • 1,10,24,25,30-pentahydroxysqualene
  • Anti-Bacterial Agents
  • Plant Extracts
  • Triterpenes
  • dammar-20(22),24-diene-3beta,26,27-triol