Abstract
Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Antigens, Polyomavirus Transforming* / analysis
-
Antigens, Polyomavirus Transforming* / genetics
-
Haplorhini
-
Humans
-
Molecular Sequence Data
-
Nuclear Proteins*
-
Papio
-
Phosphoproteins* / analysis
-
Phosphoproteins* / metabolism
-
Polyomavirus / genetics
-
Polyomavirus / immunology*
-
Protein Binding
-
Retinoblastoma Protein
-
Sequence Homology, Nucleic Acid
Substances
-
Antigens, Polyomavirus Transforming
-
Nuclear Proteins
-
Phosphoproteins
-
Retinoblastoma Protein