Cordocentesis for the diagnosis and treatment of human fetal parvovirus infection

M T Peters; K H Nicolaides

Cordocentesis for the diagnosis and treatment of human fetal parvovirus infection

Obstet Gynecol. 1990 Mar;75(3 Pt 2):501-4.

Authors

M T Peters¹, K H Nicolaides

Affiliation

¹ Department of Obstetrics and Gynecology, Harris Birthright Research Centre for Fetal Medicine, Kings College School of Medicine, Denmark Hill, London, United Kingdom.

PMID: 2154730

Abstract

Human parvovirus B-19 infection was diagnosed by DNA hybridization in blood obtained by cordocentesis from two hydropic fetuses at 22 and 26 weeks' gestation; B-19-specific immunoglobulin M (IgM) in fetal blood was negative in both cases. Hematologic studies demonstrated severe anemia, which was treated by intravascular fetal blood transfusions. The hydrops resolved and healthy infants were delivered at term. The pathophysiology of hydrops in fetal parvovirus infection is discussed.

Publication types

Case Reports

MeSH terms

Adult
Blood Specimen Collection / methods
Blood Transfusion, Intrauterine
DNA, Viral / analysis*
Female
Fetal Blood / immunology
Fetal Blood / microbiology*
Fetal Diseases / diagnosis*
Fetal Diseases / therapy
Humans
Hydrops Fetalis / etiology
Immunoglobulin G / analysis
Parvoviridae / genetics
Parvoviridae / immunology
Parvoviridae Infections / complications
Parvoviridae Infections / diagnosis*
Parvoviridae Infections / therapy
Pregnancy
Prenatal Diagnosis*

Substances

DNA, Viral
Immunoglobulin G