Cell-permeable iminocoumarine-based fluorescent dyes for mitochondria

Org Lett. 2011 Jun 3;13(11):2884-7. doi: 10.1021/ol200908r. Epub 2011 May 6.

Abstract

A class of small molecule fluorophores, 2-iminocoumarin-3-carboxamide derivatives, has been developed by a rapid microwave-assisted process. These fluorescent probes are cell membrane permeable with low cytotoxicity and able to selectively stain organelles in living cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / drug effects
  • Cell Membrane / metabolism*
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • HeLa Cells
  • Humans
  • Mitochondria / metabolism*
  • Molecular Structure

Substances

  • Coumarins
  • Fluorescent Dyes