Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

Int J Antimicrob Agents. 2011 Jul;38(1):81-3. doi: 10.1016/j.ijantimicag.2011.03.007. Epub 2011 May 5.

Abstract

Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Child, Preschool
  • Clindamycin / pharmacology*
  • Drug Resistance, Bacterial
  • Erythromycin / pharmacology
  • Female
  • Genetic Variation*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Plasmids
  • Soft Tissue Infections / microbiology
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Skin Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / isolation & purification
  • Streptogramin A / pharmacology

Substances

  • ATP-Binding Cassette Transporters
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • VgA protein, Staphylococcus aureus
  • Clindamycin
  • Erythromycin
  • Streptogramin A