Abstract
Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.
Copyright © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / genetics*
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Adolescent
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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Child, Preschool
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Clindamycin / pharmacology*
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Drug Resistance, Bacterial
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Erythromycin / pharmacology
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Female
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Genetic Variation*
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Humans
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Male
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Microbial Sensitivity Tests
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Plasmids
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Soft Tissue Infections / microbiology
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Staphylococcal Infections / microbiology*
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Staphylococcal Skin Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / isolation & purification
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Streptogramin A / pharmacology
Substances
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ATP-Binding Cassette Transporters
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Anti-Bacterial Agents
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Bacterial Proteins
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VgA protein, Staphylococcus aureus
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Clindamycin
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Erythromycin
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Streptogramin A