Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration

C H Yeong; P E Blackshaw; K H Ng; B J J Abdullah; M Blaauw; R J Dansereau; A C Perkins

doi:10.1016/j.apradiso.2011.04.017

Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration

Appl Radiat Isot. 2011 Sep;69(9):1181-4. doi: 10.1016/j.apradiso.2011.04.017. Epub 2011 Apr 22.

Authors

C H Yeong¹, P E Blackshaw, K H Ng, B J J Abdullah, M Blaauw, R J Dansereau, A C Perkins

Affiliation

¹ Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

PMID: 21550260
DOI: 10.1016/j.apradiso.2011.04.017

Abstract

Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10mg of Sm(2)O(3)) were irradiated by thermal neutrons to achieve 1 MBq at 48 h. Administered activities were 0.86±0.03 MBq. Good reproducibility (CV=3.5%) was observed over 24 weeks ensuring that volunteer doses were within the dose reference level of 0.8 mSv.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Guaifenesin / administration & dosage
Guaifenesin / analogs & derivatives*
Humans
Isotope Labeling
Neutron Activation Analysis
Radioisotopes
Reproducibility of Results
Samarium

Substances

Radioisotopes
Samarium
Guaifenesin