Diastereoselectively switchable enantioselective trapping of carbamate ammonium ylides with imines

J Am Chem Soc. 2011 Jun 8;133(22):8428-31. doi: 10.1021/ja201589k. Epub 2011 May 16.

Abstract

The diastereoselectively switchable enantioselective trapping of protic carbamate ammonium ylides with imines is reported. The intriguing Rh(2)(OAc)(4) and chiral Brønsted acid cocatalyzed three-component Mannich-type reaction of a diazo compound, a carbamate, and an imine provides rapid and efficient access to both syn- and anti-α-substituted α,β-diamino acid derivatives with a high level control of chemo-, diastereo-, and enantioselectivity.

MeSH terms

  • Carbamates / chemistry*
  • Catalysis
  • Imines / chemistry*
  • Molecular Structure
  • Phosphoric Acids / chemistry
  • Quaternary Ammonium Compounds / chemistry*
  • Rhodium / chemistry
  • Stereoisomerism

Substances

  • Carbamates
  • Imines
  • Phosphoric Acids
  • Quaternary Ammonium Compounds
  • Rhodium
  • phosphoric acid