Multifunctional Poly(2-oxazoline) Nanoparticles for Biological Applications

Kristian Kempe; Antje Vollrath; Hendrik W Schaefer; Tobias G Poehlmann; Christoph Biskup; Richard Hoogenboom; Stephanie Hornig; Ulrich S Schubert

doi:10.1002/marc.201000283

Multifunctional Poly(2-oxazoline) Nanoparticles for Biological Applications

Macromol Rapid Commun. 2010 Nov 1;31(21):1869-73. doi: 10.1002/marc.201000283.

Authors

Kristian Kempe¹, Antje Vollrath, Hendrik W Schaefer, Tobias G Poehlmann, Christoph Biskup, Richard Hoogenboom, Stephanie Hornig, Ulrich S Schubert

Affiliation

¹ Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-Universität Jena, Humboldtstrasse 10, 07743 Jena, Germany.

PMID: 21567605
DOI: 10.1002/marc.201000283

Abstract

New multifunctional copoly(2-oxazoline) nanoparticles were prepared for cell studies. The polymer contains double-bond side chains as potential reaction sites for "thio"-click reactions as well as a fluorescein label covalently bound to the polymer backbone. Using the nanoprecipitation technique, spherical nanoparticles of 200-800 nm were obtained. Confocal laser scanning microscopy measurements revealed the cellular uptake of the nanoparticles.