Neuro-endocrine disturbances were determined in juvenile depressives and possible correlations with biochemical abnormalities investigated. It was established that, as in adult depressives, the young also showed a high incidence of cortisol non-suppression after dexamethasone administration. In addition, a positive correlation observed between lymphocyte beta-adrenoceptor maximal number of binding sites and basal cortisol levels stresses the involvement of the noradrenergic neurotransmission system.