Abstract
Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal constriction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with beta-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal kappa-opioid receptors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analgesics*
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Animals
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Dose-Response Relationship, Drug
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Injections, Intraventricular
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Injections, Spinal
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Male
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Mice
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Mice, Inbred ICR
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Naltrexone / analogs & derivatives
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Naltrexone / pharmacology
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Nitrous Oxide / pharmacology*
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Pain Measurement
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Receptors, Opioid / physiology*
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Receptors, Opioid, kappa
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Spinal Cord / drug effects
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Spinal Cord / metabolism*
Substances
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Analgesics
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Receptors, Opioid
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Receptors, Opioid, kappa
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norbinaltorphimine
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Naltrexone
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beta-funaltrexamine
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Nitrous Oxide