Abstract
Expression of the alcohol dehydrogenase gene ADH1, which converts ethanol into carcinogenic acetaldehyde, significantly inversely correlated with the expression of CDR1 and CDR2, genes linked to azole resistance in Candida albicans isolated from chronic oral candidosis in autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED, APS-I) patients. This is a novel link between candidal two-carbon metabolism genes and azole resistance.
© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetaldehyde / metabolism
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Alcohol Dehydrogenase / biosynthesis*
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Alcohols / metabolism
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Antifungal Agents / metabolism
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Azoles / metabolism
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Candida albicans / genetics*
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Candida albicans / isolation & purification
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Candida albicans / metabolism*
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Candidiasis, Oral / microbiology*
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Carcinogens / metabolism
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Chronic Disease
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Fungal Proteins / biosynthesis*
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Gene Expression Regulation, Fungal*
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Humans
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Polyendocrinopathies, Autoimmune / microbiology*
Substances
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Alcohols
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Antifungal Agents
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Azoles
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Carcinogens
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Fungal Proteins
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Alcohol Dehydrogenase
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Acetaldehyde
Supplementary concepts
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Autoimmune polyendocrinopathy syndrome, type 1