Matrix metalloproteinases (MMPs) belong to a large family of multidomain zinc endopeptidases. They are one of the most important proteolytic enzymes which digest components of the extracellular matrix and take part in many physiological processes, such as apoptosis or angiogenesis. It was shown that MMPs are also involved in the pathogenesis of many diseases such as malignant tumors and cardiovascular diseases. The discovery of the mechanisms of MMPs' action can have significant influence on therapeutic strategy, especially in cardiovascular diseases.