Molecular epidemiology of HPV infection using a clinical array methodology in 2952 women in Greece

Clin Microbiol Infect. 2011 Aug;17(8):1185-8. doi: 10.1111/j.1469-0691.2011.03505.x. Epub 2011 May 20.

Abstract

The molecular epidemiology of human papillomavirus (HPV) infection in a sample of Greek women (n = 2952, mean age 42.2 ± 13.3 years) was examined. HPV prevalence was 50.7% (95% confidence interval, 48.8-52.6). The most frequent HPV types were HPV 53, 51 and 66 (10.2%, 9.4% and 9.3%, respectively). HPV positivity was associated with age, age of sexual debut, number of sexual partners and duration of sexual relationship, while marriage or multiparity protected against infection (all p <0.001). Follow-up of this cohort will assist in predicting the effect of vaccination with the new HPV vaccines on future screening with HPV-based tests for cervical cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / virology
  • Adult
  • Aged
  • Carcinoma, Squamous Cell / epidemiology*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / virology
  • DNA, Viral / analysis
  • Female
  • Greece / epidemiology
  • Humans
  • Middle Aged
  • Molecular Epidemiology
  • Papillomaviridae / classification
  • Papillomaviridae / genetics*
  • Papillomavirus Infections / diagnosis
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology
  • Prevalence
  • Reagent Kits, Diagnostic
  • Tumor Virus Infections / epidemiology*
  • Tumor Virus Infections / pathology
  • Tumor Virus Infections / virology
  • Uterine Cervical Dysplasia / epidemiology
  • Uterine Cervical Dysplasia / pathology
  • Uterine Cervical Dysplasia / virology
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / virology
  • Vaginal Smears
  • Young Adult

Substances

  • DNA, Viral
  • Reagent Kits, Diagnostic