Neuroprotective bakkenolides from the roots of Valeriana jatamansi

Fitoterapia. 2011 Sep;82(6):849-53. doi: 10.1016/j.fitote.2011.04.012. Epub 2011 May 9.

Abstract

Two new bakkenolides, valerilactones A (1), and B (2), and two known analogues, bakkenolide-H (3) and bakkenolide-B (4), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. Compounds 1, 2, and 3 exhibited potent neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Methyl-4-phenylpyridinium / toxicity
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Humans
  • Medicine, Traditional
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology*
  • Plant Extracts / chemistry*
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Valerian / chemistry*

Substances

  • Neuroprotective Agents
  • Plant Extracts
  • Sesquiterpenes
  • bakkenolide B
  • valerilactone A
  • valerilactone B
  • 1-Methyl-4-phenylpyridinium