Abstract
In Kawasaki Disease patients, the authors show associations between high-dose intravenous immunoglobulin (IVIG) response and a polymorphism in the FCγRIIB. This provides basis for defining the IVIG regulatory mechanisms and pharmacogenomic approach to IVIG therapy.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Child
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Child, Preschool
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Female
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Gene Frequency
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Genetic Variation*
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Humans
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Immunoglobulins, Intravenous / administration & dosage
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Immunoglobulins, Intravenous / therapeutic use*
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Infant
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Male
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Mice
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Mucocutaneous Lymph Node Syndrome / genetics*
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Mucocutaneous Lymph Node Syndrome / immunology
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Mucocutaneous Lymph Node Syndrome / therapy*
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Polymorphism, Genetic
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Receptors, IgG / genetics*
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Receptors, IgG / metabolism
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Treatment Outcome
Substances
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FCGR2B protein, human
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Immunoglobulins, Intravenous
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Receptors, IgG