Abstract
Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cytokines / antagonists & inhibitors
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Epithelial Cells / immunology*
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Epithelial Cells / microbiology*
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Genes, Reporter
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Humans
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Immunologic Factors / analysis
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Immunologic Factors / isolation & purification
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Luciferases / metabolism
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Molecular Weight
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NF-kappa B / antagonists & inhibitors*
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Streptococcus / chemistry
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Streptococcus / immunology*
Substances
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Cytokines
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Immunologic Factors
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NF-kappa B
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Luciferases