Abstract
Two new pentacyclic triterpenes and eight known pentacyclic triterpenes were isolated from the petroleum ether extract of Liquidambaris Resina. The structural elucidation of these compounds was determined by spectroscopic data interpretation. Their cytotoxic and antiplatelet aggregation activities were examined to find potent cytotoxic and antiplatelet aggregation compounds from natural resources. The results showed that 3-keto oleane triterpenes had strong cytotoxicity against MDA-MB-435S cancer cells and that 28-carboxyl oleane triterpenes possessed significant inhibition of platelet aggregation induced by ADP.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticoagulants / chemistry
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Anticoagulants / isolation & purification
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Anticoagulants / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Female
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Humans
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Inhibitory Concentration 50
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Liquidambar / chemistry*
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Pentacyclic Triterpenes / chemistry
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Pentacyclic Triterpenes / isolation & purification
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Pentacyclic Triterpenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Platelet Aggregation / drug effects
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Resins, Plant / chemistry
Substances
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Anticoagulants
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Antineoplastic Agents
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Pentacyclic Triterpenes
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Plant Extracts
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Resins, Plant