Pathogenesis of endemic pemphigus foliaceus

Valeria Aoki; Joaquim Xavier Sousa Jr; Luis A Diaz; Cooperative Group on Fogo Selvagem Research

doi:10.1016/j.det.2011.03.014

Pathogenesis of endemic pemphigus foliaceus

Dermatol Clin. 2011 Jul;29(3):413-8, viii. doi: 10.1016/j.det.2011.03.014.

Authors

Valeria Aoki¹, Joaquim Xavier Sousa Jr, Luis A Diaz; Cooperative Group on Fogo Selvagem Research

Affiliation

¹ Department of Dermatology, University of São Paulo Medical School, Avenida Doutor Eneas de Carvalho Aguiar, 255 Sala 3016 ICHC, São Paulo CEP 05403-002, Brazil. [email protected]

Abstract

Pemphigus refers to a group of human autoimmune blistering diseases involving skin and/or mucous membranes. Endemic pemphigus foliaceus (EPF), or fogo selvagem is an organ-specific autoimmune blistering disease, first reported in the beginning of the 20th century in rural areas of Brazil. The disease follows the course of streams and creeks, and vanishes after urbanization of the endemic areas. The auto-antigen related to EPF is desmoglein 1, a 160 kDa glycoprotein of the desmossomal core, targeted by in situ and circulating IgG autoantibodies, mainly of the IgG4 subclass.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Endemic Diseases / statistics & numerical data*
Humans
Pemphigus* / epidemiology
Pemphigus* / etiology
Pemphigus* / pathology
Skin / pathology*

Abstract

Publication types

MeSH terms

Grants and funding