Activity-based profiling of 2-oxoglutarate oxygenases

Paul P Geurink; Bogdan I Florea; Herman S Overkleeft

doi:10.1016/j.chembiol.2011.05.002

Activity-based profiling of 2-oxoglutarate oxygenases

Chem Biol. 2011 May 27;18(5):557-9. doi: 10.1016/j.chembiol.2011.05.002.

Authors

Paul P Geurink¹, Bogdan I Florea, Herman S Overkleeft

Affiliation

¹ Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands.

PMID: 21609835
DOI: 10.1016/j.chembiol.2011.05.002

Abstract

2-Oxoglutarate oxygenases (2-OGs) are a large enzyme family involved in numerous processes in health and disease. Rotili et al. (2011) describe in this issue of Chemistry & Biology an activity-based protein profiling-based strategy with which the activity of individual members of the 2-OG family can be addressed in the context of complex biological systems.

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