The abnormal in vitro response to aspirin of platelets from aspirin-sensitive asthmatics is inhibited after inhalation of nedocromil sodium but not of sodium cromoglycate

Br J Clin Pharmacol. 1990 May;29(5):525-31. doi: 10.1111/j.1365-2125.1990.tb03675.x.

Abstract

1. Blood platelets from patients with aspirin-sensitive asthma (ASA) generated cytotoxic mediators in the presence of aspirin. This abnormal in vitro response to aspirin was abolished within 1 h after nedocromil sodium inhalation but not after sodium cromoglycate inhalation. 2. Platelets recovered this reactivity to aspirin by 12 hours after nedocromil sodium treatment of ASA-patients. 3. The in vitro reactivity to aspirin of ASA platelets isolated before inhalation was inhibited in the presence of serum isolated 15 and 60 min after nedocromil sodium inhalation.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Inhalation
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Aspirin / pharmacology*
  • Asthma / physiopathology*
  • Blood Platelets / drug effects*
  • Cell Survival / drug effects
  • Cromolyn Sodium / adverse effects
  • Cromolyn Sodium / pharmacokinetics
  • Cromolyn Sodium / pharmacology*
  • Female
  • Humans
  • Indicators and Reagents
  • Male
  • Middle Aged
  • Nedocromil
  • Quinolones / administration & dosage
  • Quinolones / adverse effects
  • Quinolones / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Indicators and Reagents
  • Quinolones
  • Nedocromil
  • Cromolyn Sodium
  • Aspirin