Trafficking of stem cells

Methods Mol Biol. 2011:750:3-24. doi: 10.1007/978-1-61779-145-1_1.

Abstract

Stem cells undergo regulated trafficking from the developmental stages to the adulthood. Stem cell migration is critical to organize developing organs and likely contributes postnatally to tissue regeneration. Here, we review the molecular mechanisms underlying migration of hematopoietic stem cells, neural stem cells, and primordial germ cells, revealing common operative pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Cell Movement*
  • Central Nervous System / cytology*
  • Central Nervous System / embryology
  • Central Nervous System / physiology*
  • Chemokine CXCL12 / genetics
  • Chemokine CXCL12 / metabolism
  • Embryonic Development / physiology*
  • Gene Expression Regulation, Developmental
  • Germ Cells / cytology
  • Germ Cells / physiology*
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Mice
  • Neural Stem Cells / cytology
  • Neural Stem Cells / physiology*
  • Rats
  • Receptors, CXCR4 / genetics
  • Receptors, CXCR4 / metabolism
  • Regeneration*
  • Signal Transduction

Substances

  • Chemokine CXCL12
  • Receptors, CXCR4