Abstract
The therapeutic efficacy, changes in haematocrit and declines in parasitaemias were evaluated in 56 children with uncomplicated falciparum hyperparasitaemia after oral artesunate-amodiaquine or artemether-lumefantrine. All children recovered clinically within 2 days and without progression to severe malaria. Falls in haematocrit in the first 3 days after treatment began were similar and <5%. Declines in parasitaemias were monoexponential with both treatments with an estimated half-life of 1 h.
Publication types
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Randomized Controlled Trial
MeSH terms
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Amodiaquine / therapeutic use*
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Antimalarials / therapeutic use*
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Artemether, Lumefantrine Drug Combination
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Artemisinins / therapeutic use*
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Child
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Child, Preschool
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Drug Combinations
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Ethanolamines / therapeutic use*
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Female
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Fluorenes / therapeutic use*
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Hematocrit
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Humans
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Infant
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Malaria, Falciparum / blood
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / parasitology
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Male
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Nigeria
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Parasitemia / drug therapy
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Plasmodium falciparum
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Treatment Outcome
Substances
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Antimalarials
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Artemether, Lumefantrine Drug Combination
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Artemisinins
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Drug Combinations
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Ethanolamines
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Fluorenes
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amodiaquine, artesunate drug combination
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Amodiaquine