Abstract
Calves were vaccinated with two preparations made from one cutaneous fibropapilloma induced by bovine papillomavirus type 2 (BPV-2). One vaccine consisted of homogenised tumour; the other contained purified virus only. Both produced resistance to a heavy challenge infection of BPV-2. One calf in the vaccinated group developed a small tumour and rejected it earlier than the control calves. It would appear likely that the prophylactic immune response was induced by viral structural proteins only and that tumour-specific antigens are unnecessary. Bovine fibroblasts were transformed in vitro by BPV-2 and administered as a vaccine; immunity was not induced.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Antigens, Neoplasm / immunology
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Cattle
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Cattle Diseases / immunology
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Cattle Diseases / microbiology
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Cattle Diseases / prevention & control*
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Cell Line, Transformed
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Cell Transformation, Neoplastic
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Cell Transformation, Viral
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Fibroblasts / immunology*
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Neutralization Tests
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Papilloma / immunology
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Papilloma / veterinary*
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Papillomaviridae / immunology*
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Papillomaviridae / isolation & purification
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Tissue Extracts / immunology
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Tumor Virus Infections / immunology
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Tumor Virus Infections / prevention & control
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Tumor Virus Infections / veterinary*
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Viral Vaccines / immunology*
Substances
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Antibodies, Viral
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Antigens, Neoplasm
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Tissue Extracts
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Viral Vaccines