Objective: The insulin-like growth factor 2 (IGF2) and its receptor (IGF2R) are important regulators of placental function and fetal growth. Our aim was to investigate the association between IGF2R gene Gly1619Arg G>A polymorphism and recurrent spontaneous abortion (RSA).
Methods: Polymerase chain reaction and restriction fragment length polymorphism methods were performed to identify the genotypes in 149 couples with a history of at least three consecutive spontaneous abortions and 149 age-matched, unrelated, and fertile couples.
Results: There were no statistically significant differences in genotype or allele frequency among the couples with RSA and healthy controls.
Conclusions: We found no evidence that the IGF2R Gly1619Arg variation is associated with RSA.