A new case of benign hypertrophic gastritis associated with cytomegalovirus infection in a 7 year-old boy is reported. The main symptoms were complete digestive intolerance and protein loss, resulting in major hypoalbuminemia and anasarca. The alpha-1-antitrypsin clearance was very increased. Diagnosis was established by upper gastrointestinal x-rays which displayed important thickening of the gastric rugae, and by endoscopic examination with biopsy. A cytomegalovirus infection attested by seroconversion and viruria probably played a role in its origin. Symptomatic treatment and albumin infusions led to recovery within one month. In the last 25 years, 31 cases of benign hypertrophic gastritis have been reported. Vomiting is the main symptom with abdominal pain and G-I bleeding. The protein loss is constant, often severe. In most cases, the disease recedes within a few weeks, unlike the adults' Ménétrier disease which proves to be chronic and severe. The cause remains unknown. In 11 cases, a cytomegalovirus infection was reported and, so, is probably not fortuitous.