Primary cilia: how to keep the riff-raff in the plasma membrane

David K Breslow; Maxence V Nachury

doi:10.1016/j.cub.2011.04.039

Primary cilia: how to keep the riff-raff in the plasma membrane

Curr Biol. 2011 Jun 7;21(11):R434-6. doi: 10.1016/j.cub.2011.04.039.

Authors

David K Breslow¹, Maxence V Nachury

Affiliation

¹ Stanford University School of Medicine, Department of Molecular and Cellular Physiology, Stanford, CA 94305-5345, USA.

PMID: 21640903
DOI: 10.1016/j.cub.2011.04.039

Abstract

A recent report suggests that plasma membrane proteins are excluded from primary cilia via anchoring to the cortical actin cytoskeleton. These findings challenge the existence of a diffusion barrier at the base of the cilium.

MeSH terms

Cell Membrane / metabolism*
Cilia / metabolism*
Epithelial Cells / metabolism
Membrane Proteins / metabolism*
Models, Biological
Protein Transport
Signal Transduction

Substances

Membrane Proteins

Grants and funding

R01 GM089933/GM/NIGMS NIH HHS/United States