Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child

Patrizia Matarazzo; Gerdi Tuli; Daniele Tessaris; Francesca Verna; Ivana Rabbone; Antonella Lezo; Andrea Brunati; Mauro Salizzoni; Giulia Carbonaro; Massimo Terzolo; Giuseppe Reimondo; Mauro Papotti; Roberto Lala

doi:10.1515/jpem.2011.100

Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child

J Pediatr Endocrinol Metab. 2011;24(3-4):219-22. doi: 10.1515/jpem.2011.100.

Authors

Patrizia Matarazzo¹, Gerdi Tuli, Daniele Tessaris, Francesca Verna, Ivana Rabbone, Antonella Lezo, Andrea Brunati, Mauro Salizzoni, Giulia Carbonaro, Massimo Terzolo, Giuseppe Reimondo, Mauro Papotti, Roberto Lala

Affiliation

¹ Department of Paediatric Endocrinology and Diabetology, University of Torino, Regina Margherita Children Hospital, Torino, Italy. [email protected]

PMID: 21648297
DOI: 10.1515/jpem.2011.100

Abstract

Ectopic adrenocorticotrophic hormone (ACTH) secretion is a rare cause of Cushing syndrome in paediatric age, due to tumours arising from different tissues. To date, only 11 reports of ACTH-secreting pancreatic tumours in children and adolescents exist in the literature. We present a paediatric case of Cushing syndrome caused by ectopic ACTH secretion. This was caused by a large acinar cell carcinoma that developed in the pancreas of a 3-year-old girl.

Publication types

Case Reports

MeSH terms

Adrenocorticotropic Hormone / metabolism*
Carcinoma, Acinar Cell / complications*
Carcinoma, Acinar Cell / metabolism
Carcinoma, Acinar Cell / pathology
Child, Preschool
Combined Modality Therapy
Cushing Syndrome / etiology*
Cushing Syndrome / metabolism*
Cushing Syndrome / pathology
Digestive System Surgical Procedures
Female
Humans
Ketoconazole / therapeutic use
Pancreatic Neoplasms / complications*
Pancreatic Neoplasms / metabolism
Pancreatic Neoplasms / pathology
Treatment Outcome

Substances

Adrenocorticotropic Hormone
Ketoconazole