[Change of preoptic opiate receptors after injection of 6-OHDA into sublocus coeruleus in the rabbit]

Sheng Li Xue Bao. 1990 Apr;42(2):114-20.
[Article in Chinese]

Abstract

The formaldehyde histofluorescence method and receptor autoradiography were respectively used to investigate the distribution and densities of the catecholamine (CA) terminals and [3H]-etorphine binding sites, after 20 days of injection of 6-hydroxydopamine (6-OHDA) into N. subcoerulens of the rabbit. The results showed that both CA terminals and [3H]-etophine binding sites in the preoptic area, especially in the medial preoptic area, were reduced in 6-OHDA pretreated animals, thus suggesting the possible location of opioid receptors on the CA terminals.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Catecholamines / metabolism
  • Etorphine / metabolism
  • Female
  • Hydroxydopamines / administration & dosage
  • Hydroxydopamines / pharmacology*
  • Injections
  • Locus Coeruleus / metabolism*
  • Male
  • Microscopy, Fluorescence
  • Oxidopamine
  • Preoptic Area / metabolism*
  • Rabbits
  • Receptors, Opioid / drug effects*

Substances

  • Catecholamines
  • Hydroxydopamines
  • Receptors, Opioid
  • Etorphine
  • Oxidopamine