Abstract
Three children developed severe encephalopathy associated with human herpesvirus 6 infection. Magnetic resonance imaging of the brain showed either basal ganglia involvement or diffusion abnormalities in the cerebral white matter. Coagulopathy with hypercytokinemia was observed in 2 patients. One demonstrated thermolabile variation in carnitine palmitoyltransferase 2. These results suggest a heterogeneous pathogenic mechanism in encephalopathy associated with human herpesvirus 6 infection.
MeSH terms
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Basal Ganglia / enzymology
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Basal Ganglia / immunology
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Basal Ganglia / physiopathology*
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Basal Ganglia / virology
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Biomarkers / blood
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Brain Diseases, Metabolic / blood
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Brain Diseases, Metabolic / complications
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Brain Diseases, Metabolic / immunology
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Brain Diseases, Metabolic / physiopathology*
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Brain Diseases, Metabolic / virology
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Carnitine O-Palmitoyltransferase / blood
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Child, Preschool
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Cytokines / blood
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Cytokines / immunology
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Disseminated Intravascular Coagulation / blood
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Disseminated Intravascular Coagulation / complications
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Disseminated Intravascular Coagulation / immunology
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Disseminated Intravascular Coagulation / physiopathology*
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Disseminated Intravascular Coagulation / virology
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Electroencephalography
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Encephalitis, Viral / blood
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Encephalitis, Viral / complications
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Encephalitis, Viral / immunology
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Encephalitis, Viral / physiopathology*
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Encephalitis, Viral / virology
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Female
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Herpesvirus 6, Human
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Humans
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Infant
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Japan
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Magnetic Resonance Imaging
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Neurotoxicity Syndromes / blood
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Neurotoxicity Syndromes / complications
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Neurotoxicity Syndromes / immunology
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Neurotoxicity Syndromes / physiopathology*
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Neurotoxicity Syndromes / virology
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Polymerase Chain Reaction
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Roseolovirus Infections / blood
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Roseolovirus Infections / complications
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Roseolovirus Infections / immunology
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Roseolovirus Infections / physiopathology*
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Roseolovirus Infections / virology
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Th1-Th2 Balance
Substances
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Biomarkers
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Cytokines
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Carnitine O-Palmitoyltransferase