Abstract
Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / isolation & purification*
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Blood Vessels / drug effects
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Cell Line, Tumor
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Cell Survival / drug effects
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Drugs, Chinese Herbal / chemistry
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Embryo, Nonmammalian / drug effects
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Ethnopharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Humans
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Iridoids / chemistry
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Iridoids / isolation & purification
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Iridoids / pharmacology
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Lung Neoplasms / drug therapy
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Lung Neoplasms / pathology
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Luteolin / chemistry
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Luteolin / isolation & purification
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Luteolin / pharmacology
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Molecular Structure
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Plant Components, Aerial / chemistry*
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Sapogenins / chemistry
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Sapogenins / isolation & purification
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Sapogenins / pharmacology
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / pharmacology
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Stereoisomerism
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Verbascum / chemistry*
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Zebrafish
Substances
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3-O-fucopyranosylsaikogenin F
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Angiogenesis Inhibitors
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Glycosides
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Iridoids
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Sapogenins
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Saponins
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Luteolin