Rolling ES cells down the Waddington landscape with Oct4 and Sox2

Nicola Iovino; Giacomo Cavalli

doi:10.1016/j.cell.2011.05.027

Rolling ES cells down the Waddington landscape with Oct4 and Sox2

Cell. 2011 Jun 10;145(6):815-7. doi: 10.1016/j.cell.2011.05.027.

Authors

Nicola Iovino¹, Giacomo Cavalli

Affiliation

¹ Institut de Génétique Humaine, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France.

PMID: 21663785
DOI: 10.1016/j.cell.2011.05.027

Abstract

Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al. (2011) now show that two core components of the pluripotency circuit, Oct4 and Sox2, are also critical for germ layer fate choice.

Publication types

Comment